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MMI Course: DRUG DESIGN & DELIVERY

Title: MMI Course: DRUG DESIGN & DELIVERY

Date(s): 17-18 & 21-22 April 2008 (0930-1300 each day)

Online Application Period: 18 Mar - 9 Apr 2008

Venue: Albert Lecture Theatre, the Royal College of Surgeons in Ireland (location)


Download the course poster
here 

  

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Programme


Faculty

This course is designed to give clinicians and researchers from the life, chemical and physical sciences a broad overview of the concepts, strategies and research techniques used in drug discovery and delivery. Basic understanding of molecular structures would be an advantage but is not required and you should not need prior knowledge of the models and techniques covered in the course.

The objective for postgraduate teaching is to give students an overview and illustration of how the interaction of a drug target (generally a protein) with a small molecule or a macromolecule can be optimised (in silico or in vitro) to develop a pharmaceutical or bio-pharmaceutical agent. Besides the optimisation of the affinity and selectivity of these drug candidates for the therapeutic target, other key issues to be considered at the drug discovery & development stages, such as absorption, distribution, metabolism and excretion (ADME) properties, protection of the intellectual property and regulatory affairs will also be introduced. Many promising and highly active new drugs never go beyond the laboratory because of problems associated with their formulation and delivery. A series of drug delivery lectures will highlight the impact of drug structure and design on a molecule’s pharmaceutical and biopharmaceutical properties and ultimately on its’ pharmaceutical development into a final product. Specific lectures will cover the challenges associated with the delivery of macromolecules.

We recommend that postgraduate students attend the whole course (DMMC Course Attendance Certificates are only provided for complete attendance). 

Day 1: Thu 17 Apr; 0930-1300

0930 From genes to drugs
Dr Marc Devocelle (RCSI)
1015 Molecular basis of drug action: drug receptor interactions
Dr Isabel Rozas (TCD)
1100 Coffee/Tea
1130 Molecular basis of drug action: catalytic receptors, enzymes and their inhibition Dr John Gilmer (TCD)
1215 Natural products as leads in drug design
Dr James Barlow (RCSI)
1300 Lunch is provided
  Click here to read an abstract of each lecture

Day 2: Fri 18 Apr; 0930-1300

0930 The concept of pharmacophore: biological perspective
Prof Niamh Moran (RCSI)
1015 The concept of pharmacophore: informatics perspective
Prof Denis Shields (UCD)
1100 Coffee/Tea
1130 IP issues in drug design
Mr Colin Sainsbury (BCM Hanby Wallace)
1215 The impact of regulatory affairs in drug discovery
Dr Christine Marey (Servier)
1300 Lunch is provided
  Click here to read an abstract of each lecture

 Day 3: Mon 21 Apr; 0930-1430

0930 Rational drug design: structure/activity relationships
Dr Isabel Rozas (TCD)
1015 Rational computer-aided drug design
Dr Darren Fayne (TCD)
1100 Coffee/Tea
1130 Techniques in rational drug design: X-ray crystallography
Dr Amir Khan (TCD)
1215 Case studies in drug design and development
Prof Mary Meegan (TCD)
1300 Lunch is provided
1345 Drug discovery within the Pharmaceutical Industry
Prof Bertrand Castro (Scientific Director Industrial Affairs, Sanofi-Aventis)
  Click here to read an abstract of each lecture
 

Day 4: Tue 22 Apr; 0930-1300
The Lectures in this session are provided by investigators in the Irish Drug Delivery Network

0930 The role of drug delivery in drug design
and development
Dr Sally-Ann Cryan (RCSI)
1015 Delivery of protein-based therapeutics: challenges and opportunities
Prof David Brayden (UCD)
1100 Coffee/Tea
1130 Drug distribution and targeting
Prof Caitriona O’Driscoll (UCC)
1215 Gene Delivery: from molecular packaging to targeting
Prof Caitriona O’Driscoll (UCC)
1300 Lunch is provided
  Click here to read an abstract of each lecture

Course Instructors
Course Coordinator: Dr Marc Devocelle (Department of Pharmaceutical Chemistry, RCSI)

Dr James Barlow (School of Pharmacy, RCSI)
Prof David Brayden (UCD School of Agriculture, Food Science, & Veterinary Medicine and UCD Conway Institute)
Prof Bertrand Castro (Scientific Director Industrial Affairs, Sanofi-Aventis)
Dr Sally-Ann Cryan (School of Pharmacy, RCSI)
Dr Raphael Darcy (UCD School of Chemistry & Chemical Biology and Conway Institute)
Dr Darren Fayne (Molecular Design Group, School of Biochemistry and Immunology, TCD)
Dr John Gilmer (School of Pharmacy & Pharmaceutical Sciences, TCD)
Dr Amir Khan (School of Biochemistry and Immunology, TCD)
Dr Christine Marey (Pre-submission Division Director (Worldwide Regulatory Affairs), Servier Research Group)
Prof Mary Meegan (School of Pharmacy & Pharmaceutical Sciences, TCD)
Prof Niamh Moran (Department of Clinical Pharmacology, RCSI)
Prof Caitriona O’Driscoll (School of Pharmacy, UCC)
Dr Isabel Rozas (School of Chemistry, TCD)
Mr Colin Sainsbury (Partner, BCM Hanby Wallace)
Prof Denis Shields (UCD Conway Institute of Biomolecular & Biomedical Research)

 

Online Application has closed.