Course Information

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Date(s): Wednesday 11 June

Main Venue:
Institute of Molecular Medicine
Trinity Centre for Health Sciences, St James's Hospital, James's Street, Dublin 8

Location »

Online Application Period: 12 May - 9 Jun 2008


Download the course poster

IMPORTANT: This course comprises a lecture element (Day 1) and a practical workshop (Day 2). Please note that there is a limited number of places available for the practical workshop.

You must first apply online here. If you only wish to attend the lecture element of the course (Day 1), this is all what you need to do at this stage.
If you also wish to attend the practical workshop (Day 2), then after applying online, please send an Email to expressing your interest.
Please note that those attending the practical workshop must also attend the lecture element of the course. 


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The analysis of genetic determinants in human disease, particularly in multifactorial conditions such as cardiovascular disease, has advanced markedly in recent years due to the availability of high-density maps of Single Nucleotide Polymorphism (SNP) markers, new insights into human genome structure from the International HapMap Project and novel analytical methods. This course, running over two days, aims to introduce researchers to key strategic considerations in designing and performing gene-mapping studies using SNP markers. It will also provide ‘hands-on’ experience of data analysis.

Day 1 (10 June) will focus on the nature and dynamics of SNP markers in populations, associations between markers due to the haplotype ‘block’ structure of the human genome and public domain resources for gene-mapping studies. Talks on applying these tools to clinical problems and the evolution of populations includes two Plenary Lectures on Epilepsy genomics (Dr Sanjay Sisodiya, University College London Hospital) and Population genomics of human gene (Dr Emmanouil T. Dermitzakis, Wellcome Trust Sanger Institute). Please see here for more information on Day 1

Day 2 (11 June) is designed as a ‘hands-on’ practical workshop that examines resources for selecting SNPs, issues around study design & power and data management, and will give time for some basic analyses of SNP data.


Day 2 - PRACTICAL WORKSHOP: WED 11 June (1030-1630)
Lead Instructor: Dr Ross McManus (TCD)


Topics to be covered include:

  • Generating haplotypes
  • Tagging SNPs
  • Association analysis
  • Data management
  • Basic statistical analysis
  • Using Hapmap
  • Genetic database

    Lunch is provided
Course Coordinators
Prof David Croke (Molecular & Cellular Therapeutics, RCSI)
Dr Ross McManus (Institute of Molecular Medicine, St James's Hospital, TCD)
Prof Denis Shields (UCD Conway Institute of Biomolecular & Biomedical Research)Workshop Instructors
Dr Ross McManus (Institute of Molecular Medicine, St James's Hospital, TCD)
Dr Derek Morris (Institute of Molecular Medicine, St James's Hospital, TCD)
Dr Anthony Ryan (Institute of Molecular Medicine, TCD)


Online Application has closed.